Senior Biostatistician, Biostatistics, R&D, Orion Corporation

Join a growing oncology‑focused Data Sciences function and provide statistical support across Phase I–III oncology studies. The Senior Biostatistician contributes to the design, analysis, interpretation and reporting of oncology clinical trials. With a particular focus on biomarker, translational, and precision medicine analyses, you collaborate closely with Clinical Development, Translational Medicine, Data Sciences, Statistical Programming, and external partners to deliver high‑quality statistical solutions throughout the drug development lifecycle.

This role can be based in Cambridge, MA or Cambridge, UK and reports to the Head of Biostatistics.

Responsibilities

• Contribute to the design and statistical sections of clinical trial protocols, including endpoint selection, sample size considerations, and randomization approaches.
• Support analyses of predictive, prognostic, pharmacodynamic, and other biomarker data to inform development decisions and patient selection strategies.
• Participate in the integration and interpretation of clinical and biomarker findings to generate actionable insights.
• Plan, prepare, and execute statistical analyses according to SAPs.
• Generate and review tables, listings, and figures (TLFs).
• Ensure statistical deliverables adhere to CDISC standards (SDTM, ADaM).
• Support clinical study reporting and regulatory documents.
• Collaborate with clinical, data management, and programming teams throughout the study lifecycle.
• Contribute to the evaluation and appropriate use of AI‑assisted tools, automation, and advanced analytics approaches that enhance statistical efficiency and insight generation.

Qualifications

• PhD or MS in Statistics, Biostatistics, or related field.
• MS with approximately 4–8 years, or PhD with 2–5 years, of relevant experience in clinical development, oncology preferred.
• Strong understanding of statistical methods and their application in drug development.
• Proficiency in SAS (required); working knowledge of R.
• Demonstrated interest in applying AI‑enabled approaches to improve statistical workflows, data analysis efficiency, visualization, and decision support.

Expected annual salary range: USD 100,000–180,000 for U.S. candidates, depending on skills, experience, and job‑related qualifications. For UK‑based candidates, compensation will be aligned with Orion’s salary range for the applicable grade.